Zyprexa and Smoking: Drug Interaction
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Many interactions between tobacco smoke and medications have been identified. Note that it is the tobacco smoke — not the nicotine – that causes these drug interactions. Tobacco smoke may interact with medications through pharmacokinetic or pharmacodynamic mechanisms. Pharmacokinetic interactions affect the absorption, distribution, metabolism, or elimination of other drugs, potentially causing an altered pharmacologic response. The majority of pharmacokinetic interactions are the result of induction of hepatic cytochrome P450 enzymes (primarily CYP1A2). Pharmacodynamic interactions alter the expected response or actions of other drugs. The amount of tobacco smoking needed to have an effect has not been established and the assumption is that any smoker is susceptible to the same degree of interaction.
| DRUG/CLASS | MECHANISM OF INTERACTION AND EFFECTS |
|---|---|
| Pharmacokinetic Interactions | |
| Olanzapine (Zyprexa) |
|
| Pharmacodynamic Interactions | |
|---|---|
| Benzodiazepines (diazepam, chlordiazepoxide) |
|
| Beta-blockers |
|
| Opioids (propoxyphene, pentazocine) |
|
| Oral contraceptives |
|
Archived in: Medicines, Mental Deseases
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Zyprexa for post-partum anxiety?
Since having a baby 18 mos. ago I've been experiencing increased anxiety, insomnia, temper, etc. And recently it's been exacerbated by some major life changes. I started going to counseling, and recently went to the doctor in search of some additional help. My doctor prescribed Zyprexa as a mood stabilizer. I looked up info on the web and i
